منابع مشابه
Chemotherapy-induced immunosuppression.
Chemotherapeutic agents are used widely in clinical medicine for the treatment of conditions where diminution of the host immune response is a goal. The clinical use of immunosuppression is indicated for immunologically mediated disease, lymphoproliferative diseases, and prevention of graft rejection. Five categories of agents are useful for these purposes; they are ionizing irradiation, cortic...
متن کاملBacterial Cell Wall-induced Immunosuppression
Asingle intraperitoneal injection of bacterial cell walls derived from groupA streptococci (SCW)' into susceptible rats results in the development of acute and chronic erosive polyarthritis (1, 2) . The pathology of the lesion leading to joint destruction has been shown to be aT cell-dependent, cell-mediated response to the deposition of the group A streptococcal peptidoglycan-polysaccharide po...
متن کاملImmunosuppression Induced by HIV Infection
Immunosuppression due to HIV infection is a resultant of several factors including defective innate signaling pathways, increased viral replication and virus load, gradual loss of peripheral CD4+T cells and depletion of T lymphocytes at mucosal sites that collectively lead to progressive immune deficiency and AIDS development. T cells derived from HIV patients were anergic and failed to mount a...
متن کاملMechanisms of UV-induced immunosuppression.
Ultraviolet radiation (UV), in particular the UVB range, suppresses the immune system in several ways. UVB inhibits antigen presentation, induces the release of immunosuppressive cytokines and causes apoptosis of leukocytes. UVB, however, does not cause general immunosuppression but rather inhibits immune reactions in an antigen-specific fashion. Application of contact allergens onto UV-exposed...
متن کاملImmunosuppression associated with novel chemotherapy agents and monoclonal antibodies.
The introduction of novel agents to the therapeutic armamentarium for oncologic, rheumatologic, and neurologic disorders has resulted in major clinical advances. These agents impact immune function, resulting in a discrete spectrum of infectious complications. Purine analogues and alemtuzumab alter cell-mediated immunity, resulting in opportunistic viral/fungal infections. Herpes zoster inciden...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1982
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.824321